10/15/2023 0 Comments Download cholecalciferol tablet![]() There is a time lag of 10 to 24 hours between the administration of Vitamin D and the initiation of its action in the body due to the necessity of synthesis of the active metabolites in the liver and kidneys. ![]() Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules. Vitamin D metabolites promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization. The first hydroxylation of Vitamin D takes place in the liver (to 25-hydroxyVitamin D) and the second in the kidneys (to 1,25-dihydroxyVitamin D). ![]() The in vivo synthesis of the major biologically active metabolites of Vitamin D occurs in two steps. Related/similar drugs acetylcysteine, ascorbic acid, biotin, Vitamin C, multivitamin, niacin Roxifol-D - Clinical Pharmacology
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